1. Cardiovascular disease is the direct consequence of theinability for endogenous ascorbate production in man in combination with low dietary ascorbate intake
2. Ascorbate deficiency leads to increased permeability of the vascular wall by the loss of the endothelial barrier function and the loosening of the vascular connective tissue.
3. After the loss of endogenous ascorbate production scurvy and fatal blood loss through the scorbutic vascular wall rendered our ancestors in danger of extinction.